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  • Gestational Trophoblastic Neoplasia Risk Factors

    The major risk factors for developing GTD are advanced maternal age and history of previous GTD.

    Risk factors:

    • Advanced maternal age: this is the highest risk factor for the development of GTD. Women over the age of 35 have a significantly increased risk of GTD; as many as 50% of pregnancies in women greater than age 50 are molar pregnancies.
    • History of previous GTD: a ten-fold increase in risk of GTD is observed if a woman has had a prior molar pregnancy (1% vs. 0.1%). That risk increases to 20-25% if a woman has had two or more molar pregnancies.
    • Smoking: smoking more than 15 cigarettes per day is associated with an increased risk of GTD.
    • History of infertility
    • Maternal blood type AB, A, or B