When breast cancer cells have hormone receptors, special proteins that the hormones estrogen and progesterone bind to, it is classified as hormone receptor-positive breast cancer.
Nearly two-thirds of invasive breast cancers are classified as hormone receptor-positive, including both estrogen receptor-positive (ER+) and progesterone receptor-positive (PR+) status. ER+ and PR+ tumors have a better prognosis and can require less aggressive treatment than hormone-negative cancers.